Effects of lithium on cortical thickness and hippocampal subfield volumes in psychotic bipolar disorder
نویسندگان
چکیده
منابع مشابه
Effects of lithium on cortical thickness and hippocampal subfield volumes in psychotic bipolar disorder.
Relative to healthy controls, lithium free bipolar patients exhibit significant gray matter abnormalities. Lithium, the long-time reference standard medication treatment for bipolar disorder, has been proposed to be neuro-protective against these abnormalities. However, its effects on cortical thickness and hippocampal subfield (HSF) volumes remain unstudied and unclear, respectively, in bipola...
متن کاملCortical thickness and subcortical volumes in schizophrenia and bipolar disorder.
BACKGROUND Schizophrenia and bipolar disorder are severe psychiatric diseases with overlapping symptomatology. Widespread brain morphologic abnormalities, including cortical thinning and subcortical volume reductions, have been demonstrated in schizophrenia but it is unclear whether similar abnormalities are present in bipolar disorder. The purpose of this study was to compare cortical thicknes...
متن کاملNeuroprotective effect of lithium on hippocampal volumes in bipolar disorder independent of long-term treatment response.
BACKGROUND Neuroimaging studies have demonstrated an association between lithium (Li) treatment and brain structure in human subjects. A crucial unresolved question is whether this association reflects direct neurochemical effects of Li or indirect effects secondary to treatment or prevention of episodes of bipolar disorder (BD). METHOD To address this knowledge gap, we compared manually trac...
متن کاملComparison of hippocampal volumes in schizophrenia, schizoaffective and bipolar disorder.
The reduction of hippocampal volume was frequently reported in schizophrenia, but not in bipolar disorder This volume reduction is associated with clinical features of schizophrenia, in particular with working and verbal memory impairments. Schizoaffective disorder, as a specific disorder sharing clinical features of both schizophrenia and bipolar disorder is rarely analyzed as a separate disor...
متن کاملHippocampal volumes in bipolar disorders: opposing effects of illness burden and lithium treatment.
OBJECTIVE Hippocampal volume decrease associated with illness burden is among the most replicated findings in unipolar depression. The absence of hippocampal volume changes in most studies of individuals with bipolar disorder (BD) may reflect neuroprotective effects of lithium (Li). METHODS We recruited 17 BD patients from specialized Li clinics, with at least two years of regularly monitored...
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ژورنال
عنوان ژورنال: Journal of Psychiatric Research
سال: 2015
ISSN: 0022-3956
DOI: 10.1016/j.jpsychires.2014.12.008